0704-883-0675     |      dataprojectng@gmail.com

COMPARISON OF THE EFFECTS OF CIMETIDINE AND TRAMADOL ON THE DISPOSITION OF PARACETAMOL IN HEALTHY HUMAN VOLUNTEERS

  • Project Research
  • 1-5 Chapters
  • Abstract : Available
  • Table of Content: Available
  • Reference Style: APA
  • Recommended for : Student Researchers
  • NGN 5000

ABSTRACT

The influence of cimetidine (400mg) and Tramadol (100mg) on the disposition of oral single dose (1g) Paracetamol was studied and compared in 8 healthy human volunteers under two protocols; concomitant and delayed paracetamol administration. Subjects received one treatment at each of five sessions 2wk apart. Ingestion of Paracetamol (1g) alone was used as control and compared with paracetamol concentration on concomitant (with tramadol (100mg) and then cimetidine (1g)) and delayed administration (1h 45mins after tramadol and 1h after cimetidine). Saliva paracetamol concentrations were determined with UV-Spectrophotometer. Pharmacokinetic parameters (kab, t1/2ab, kel, t1/2el and lag time), were determined by plotting paracetamol concentrations against time on a logarithmic scale while other parameters were calculated. For the influence of cimetidine and tramadol on paracetamol when either of the drugs was administered concomitantly with the paracetamol there were no significant changes (P>0.05) when compared to the control. On delayed administration of paracetamol 1h 45mins after tramadol however, Tmax and t1/2ab were significantly (P0.05). Delayed administration of paracetamol 1hour after cimetidine on the other hand affected all the pharmacokinetic parameters significantly. The (Cmax) and kab were significantly reduced (P<0.05) by 31.38% and 50.24% respectively, while Tmax, t 1 /2ab and lag-time were significantly increased (P<0.05) by 45.65%, 46.65% and vii 36.41% respectively. The t1 /2el and AUCo-∞ were also significantly increased (P<0.50) by 59.31% and 29.45% respectively. Clearance (cl) and kel on the other hand were significantly reduced (P<0.050) by 21.90% and 59.74% respectively. The volume of distribution (vd) was significantly increased by 47.30%. These findings indicated that cimetidine and tramadol do not affect the pharmacokinetics of paracetamol when either drug was taken concomitantly with paracetamol. However, when paracetamol is administered 1h 45mins after tramadol (100mg), there was a significant delay in the absorption of paracetamol, but the elimination is not significantly affected. There is both impaired absorption and inhibited metabolism of paracetamol when the administration was delayed 1 hour after cimetidine.




FIND OTHER RELATED TOPICS


Related Project Materials

An Evaluation of Waste Disposal Practices and Their Impact on Groundwater Quality in Niger State

Background of the Study
Effective waste management is a critical component of public health, particularly...

Read more
PATHOGENICITY of Heterodera sacchari (LUC AND MERNY) AND ITS INTERACTION WITH Botryodiplodia theobromae (PAT) ON SOME NERICA RICE CULTIVARS

ABSTRACT

The Cyst Nematode (CN), Heterodera sacchari, is an important pest that causes yield losses of upland rice. NERICA Rice (NR) is a...

Read more
An Appraisal of the Effects of Land Tenure Systems on Agricultural Efficiency in Nigeria

Background of the Study
Land tenure systems determine how land is owned, managed, and transferred, and the...

Read more
The Effect of Visual Storytelling on Nigerian Morphology: A Case Study of Instagram Captions

Background of the Study
Visual storytelling on Instagram has revolutionized how language and imagery interact, influencing...

Read more
An appraisal of portfolio diversification in investment banking: a case study of United Bank for Africa

Background of the Study
Portfolio diversification is a fundamental strategy used by investment banks to mitigate risk and e...

Read more
INFLUENCE OF PRICING STRATEGY ON THE SALES OF NEW PRODUCT

ABSTRACT

This project aims at examining pricing strategy and profit planning as a general pheno...

Read more
THE ROLE OF COMMERCIAL BANKS IN SMALL SCALE ENTREPRENEURIAL DEVELOPMENT IN ENUGU STATE

ABSTRACT

The subject matter of this research work is to evaluate the extent to which Small Scale entrepreneurs in Enugu have been abl...

Read more
An Investigation of Nurses' Role in Managing Chronic Obstructive Pulmonary Disease (COPD) Patients in Borno State Teaching Hospital

Background of the Study

Chronic Obstructive Pulmonary Disease (COPD) is a leading cause of morbidity...

Read more
An Assessment of Nurses' Knowledge of HIV/AIDS Prevention and Management in Osun State Specialist Hospital

Background of the Study

Human Immunodeficiency Virus (HIV) and acquired immunodeficiency syndrome (AIDS...

Read more
NOISE POLLUTION AND COMMUNICATION INTERVENTION INITIATIVES- A STUDY OF ONITSHA AND OGBETE MAIN MARKETS TRADERS’ AWARENESS AND KNOWLEDGE OF HEALTH RISKS AND ACTION

Background of the Study

Noise pollution is an environmental issue that is rapidly increasing in most parts of the world and it is capable...

Read more
Share this page with your friends




whatsapp